Androgens downregulate BMP2 impairing the inductive role of dermal papilla cells on hair follicle stem cells differentiation

Hair follicle cyclical regeneration is regulated by epithelial-mesenchymal interactions. During androgenetic alopecia (AGA), hair stem cells (HFSC) differentiation impaired deregulation of dermal papilla (DPC) secreted factors. We analyzed androgen influence on BMPs expression in DPC and their effect HFSC to lineage. Androgens downregulated BMP2 BMP4 spheroids. Addition restored alkaline phosphatase activity, marker hair-inductivity DPC, DPC-induced differentiation, both inhibited androgens. Concomitantly, differentiating HFSC, an upregulation BMPRIa BMPRII receptors nuclear β-catenin accumulation, indicative Wnt/β-catenin pathway activation, were detected. Our results present as androgen-downregulated paracrine factor that contributes inductivity favors lineage, possibly through a crosstalk with pathway. A comprehensive understanding androgen-deregulated factors effects would help improve treatments for AGA.